Brainspotting

Accentia Biopharmaceuticals acquires worldwide exclusive license to Revimmune

Buddy — Thu, 01 Mar 2007 04:55:48 +0000

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Pregnancy Hormone May Offer Treatment For Multiple Sclerosis

Buddy — Tue, 27 Feb 2007 06:52:12 +0000

Finally some news after a long stretch of not posting anything.

Medical News Today is carrying a story that links prolactin, a hormone associated with pregnancy, to nerve repair in patients with multiple sclerosis. While it is widely understood that pregnant women often see a reduction in MS relapse rates, this represents the first research pointing to remyelination during pregnancy. In an animal-based study published in the Journal of Neuroscience, researchers observed remarkable degrees of remyelination in pregnant mice vs. their non-pregnant counterparts. They also reproduced the effects without pregnancy by dosing mice with prolactin, giving hope that a similar treatment could eventually be used to treat humans affected by MS, stroke, or spinal cord injuries. More info at the link below.

Pregnancy Hormone May Offer Treatment For Multiple Sclerosis

Neuroscientists discover soy-based substance may help patients with MS

Buddy — Tue, 19 Dec 2006 05:56:57 +0000

Yes, it sounds like hippie science, but it’s true nonetheless. Jefferson Medical College researchers recently discovered that giving doses of a soy-derived substance called Bowmann-Birk Inhibitor Concentrate (BBIC) resulted in motor improvements of animals with EAE, our favorite animal model of MS. Further, animals receiving BBIC were found to have noticeable reductions of CNS inflammation and demyelination vs. animals receiving a placebo.

BBIC has the potential of being delivered orally and/or in conjunction with existing MS therapies such as beta interferons.

ScienceDaily: Natural, Soy-based Substance Might Help Fight Multiple Sclerosis, Neuroscientists Find

New discovery may help develop a test for impending MS relapses

Buddy — Tue, 05 Dec 2006 17:42:55 +0000

via Business Wire - Scientists at Stanford University School of Medicine have identified a link between a protein known as osteopontin and onset of multiple sclerosis flare-ups. Using the standard mouse model of MS, a correlation was observed between disease activity and elevated levels of osteopontin in brain tissue. Further, they were able to induce relapses by giving osteopontin to mice with the MS-like disease.

One possible outcome of this research is the development of a test for impending relapses that would enable physicians to get in front of flare-ups with prophylactic preventative medication instead of waiting and reacting. A more distant possibility is the development of antibodies that work against osteopontin to reduce flare-ups by inhibiting the lifespan of the T-cells responsible for demyelination. In either case, the findings are interesting in that they represent a new potential approach for managing the disease in the future.
Molecule Linked to Autoimmune Disease Relapses Identified at Stanford

SUNY researchers nearly halt MS progression in lab mice

Buddy — Tue, 05 Dec 2006 00:10:50 +0000

via Science Daily - Researchers at SUNY Downstate Medical Center recently isolated a compound that halts the progression of an animal model of MS (I’m assuming that means EAE, but the article doesn’t specify) in lab mice. Using an injected or orally administered compound that inhibits enzymes thought responsible for demyelination, scientists were able to produce a near complete cessation of disease progress.
It is hoped that continued research will result in significant progress in addressing both the acute and chronic phases of multiple sclerosis and other autoimmune diseases.
ScienceDaily: Substance Inhibits Progress Of Multiple Sclerosis In Animal Model

Betaseron/Betaferon approved in Australia for early MS

Buddy — Fri, 01 Dec 2006 03:44:08 +0000

Wow - long time, no post.

Medical News Today reports that following earlier expansions in other countries (USA, Canada, and Europe), Australia has broadened Betaseron’s approval to include patients with a clinically isolated episode suggestive of MS. This decision was reached following release of data from a safety and efficacy study showing, among other things, a 50% reduction in the risk (vs. placebo) of developing clinically definite MS when Betaseron/Betaferon treatment was begun by patients with initial clinical signs of the disease.

Link to article

Oral Cladribine granted Fast Track status by FDA

Buddy — Tue, 14 Nov 2006 21:28:55 +0000

Okay, it’s somewhat old news (September 21) but this blog is brand new and I can’t pass up a good story on the MS drug pipeline.

Serono, the company behind MS approved therapies Rebif and Novantrone, announced that their experimental oral packaging of the historically leukemia focused drug Cladribine has been granted Fast Track status by the FDA. The Phase III trial, which should complete enrollment by the end of the year, will span greater than 1200 patients across 17 institutions in the US. This makes it one of the largest MS drug trials ever conducted in the United States.

Cladribine joins FTY720 (Fingolimod) as an oral therapy candidate for Relapsing-Remitting MS.

Link to article

First patients dosed in Tovaxin Phase IIb trial

Buddy — Mon, 13 Nov 2006 23:36:29 +0000

Genetic Engineering News reports that Opexa Pharmaceuticals has begun dosing patients in its 150-patient Phase IIb trial of Tovaxin, a T-cell vaccine. Tovaxin is interesting because it works by provoking an immune response against the T-cells responsible for the demyelination that occurs in multiple sclerosis. Treatment involves extracting myelin peptide reactive T-cells from a blood sample, culturing a large population of them using stem cells (adult - not embryonic - so no political worries), radiating them so they can’t replicate, and finally introducing them back into the blood stream. Once reintroduced, the immune system recognizes them as foreign and generates antibodies that then go on to work against other T-cells responsible for MS. Boosters are needed periodically thereafter, but early results have been dramatic, citing upwards of 90% reductions in relapse rates for earlier trials.

While not a cure, and a long way from being proved out in terms of safety and efficacy, it’s obviously exciting to hear numbers like 90% tossed around in press releases.

Link to article

Biogen announces Avonex availablility in Japan

Buddy — Thu, 09 Nov 2006 03:10:23 +0000

Genetic Engineering News reports that Biogen has been granted permission by the Japanese Ministry of Health, Labor and Welfare to market Avonex (interferon beta-1a) in Japan. This means that Avonex joins Betaseron (marketed in Europe and Japan as ‘Betaferon’) as the second disease modifying long term therapy for individuals living with multiple sclerosis. While MS is relatively uncommon in Japan, it is estimated that some 12,000 Japanese are living with the disease today.

The addition of Avonex nicely diversifies the available treatments for MS in Japan to a total of two different interferons (beta-1a vs. beta-1b) and two different methods of injection (subcutaneous every other day vs. intramuscular once per week).
Link to article

Biogen, Teva report positive financial results for third quarter

Buddy — Thu, 02 Nov 2006 00:03:42 +0000

Two major multiple sclerosis therapy manufacturers announced third quarter earnings on Tuesday, beating estimates. Pointing to Copaxone as a major revenue driver, Teva increased US sales of the daily injection therapy by 10% over the third quarter of 2005 to reach $226 million. For Biogen’s part, Avonex led revenue growth with worldwide sales up 19% to $445 million over same quarter last year. Biogen also claimed over 2,200 Tysabri patients with worldwide sales totaling $8 million for Q3 (same quarter 2005 numbers are unavailable since Tysabri was unavailable at the time).

The business of treating diseases for profit is always a heated topic, but as long as these companies continue improving the landscape of available MS therapies, here’s hoping they continue to stay in good financial health.
Teva press release
Biogen press release